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[DOI] [PMC free article] [PubMed] [Google Scholar] 116.Lpez-Erauskin J., Fourcade S., Galino J., Ruiz M., Schluter A., Naudi A., Jov M., Portero-Otin M., Pamplona R., Ferrer I., et al

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Further, NO reduces oxidative phosphorylation by nitrosylation, inhibiting proteins involved in the mitochondrial electron transport chain

, Kim1 expression increased with higher doses of sulfasalazine (Supplemental Figure 6), suggesting a dose-dependent nephrotoxic effect

Through this direct targeting, miR-34a effectively downregulates SIRT1, resulting in the reactivation of p53s downstream effector p21 and promoting cell-cycle arrest in cancer cells