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Ovarian carcinoma cell lines (OVCAR3, SKOV3, ES2) are characterized by a high NOS1 expression resulting from the increased cell proliferation, invasion, and chemoresistance [46]

Chemotherapy-induced peripheral neuropathy is promoted by enhanced spinal insulin-like growth factor-1 levels via astrocyte-dependent mechanisms

Preclinical studies have shown that 8-Hydroxyquinoline derivatives such as clioquinol, HLA-20, and M-30 possess strong iron-chelating and free radical scavenging properties, demonstrating potential for treating neurodegenerative diseases [120]

Glutathione is a natural antioxidant thats safe for most people when administered by trained professionals

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Based on this concept, Zhang et al