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Aberrant hypermethylation of promoter regions results in gene silencing, either by preventing transcription factor binding or by facilitating the recruitment of repressor complexes, whereas hypomethylation may inappropriately activate normally silenced genes, thereby promoting genomic instability and dysregulated gene expression [110]

10.1128/MCB.24.24.10933-10940.2004 113 PrydeK

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MIC B12 injections are increasingly used as a supportive therapy in weight loss programs