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HDAC9 colocalized with the neuronal marker NeuN, but not with the astrocyte marker GFAP or the microglia marker IBA1 (Fig

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In 1997, De Flora et al demonstrated that oral administration of NAC (600mg, bid) significantly improved cell-mediated immunity, shifting from anergy to normoergy in seniors (Figure 1A).21 Anergy represents a lack of reaction from immune cells to foreign substances, such as bacteria and viruses

For example, tanshinone IIA (from Salvia miltiorrhiza or Danshen) and various flavonoids (e.g