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In turn, this may contribute to the development of depression by increasing oxidative stress, DNA damage, and cell death in the body ( A 2020 study with 132 children and teens, 89 with and 43 without depression, found that the participants with depression had lower B12 levels and higher levels of homocysteine compared with those without depression ( In addition to depressive symptoms, low or deficient B12 levels may lead to other mental conditions, including psychosis and mood disorders ( Because a deficiency in B12 negatively impacts the central nervous system, people with low or deficient B12 levels may feel foggy-headed and have difficulty concentrating and completing tasks ( Fortunately, studies show that mental impairment related to low B12 levels can improve with B12 treatment

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Mitochondrial dysfunction associated with A and tau pathology in AD includes decreased ATP production, mitophagy, biogenesis (decreased expression of peroxisome proliferator-activated receptor gamma coactivator 1-alpha, PGC-1), activity of components of the OXPHOS system and other enzymes (e.g., 17-hydroxysteroid dehydrogenase type 10, HSD-10), mitochondrial membrane potential ( m ), and import of mitochondrial proteins, imbalance of mitochondrial dynamics (upregulation of dynamin-like protein-1, DRP-1), impairment of intracellular Ca 2+ homeostasis, membrane damage, interaction with adenine nucleotide translocator 1 (ANT1) and voltage-dependent anion channel 1 (VDAC1), and increased ROS production, apoptosis (increased cytochrome c release), and mPTP opening [8,63,68,72,73,74] (Figure 2)

Nerve impulse transmission Choline is a precursor for acetylcholine, an important neurotransmitter synthesized by cholinergic neurons and involved in muscle control, circadian rhythm, memory, and many other neuronal functions

This suppression has been shown to correlate with disease severity and mortality [52]

Clinical Trials Requires FDA IND (Investigational New Drug) application IRB (Institutional Review Board) oversight Strict protocols and monitoring This is RESEARCH, not treatment 2