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it is a physiological intervention

5 Challenges and prospective Despite the notable progress made in the development and application of nanoencapsulation, considerable challenges still need to be addressed before its full potential in nutraceuticals can be realized

MRgFUS therefore represents a potentially useful adjunct platform for improving the brain delivery of biologics and other disease-modifying therapies, although further studies are needed to establish its long-term safety and clinical efficacy (Rezai et al., 2022)

& Hlebowicz, J

There was Nos1 (decreased expression), Nos2 (increased expression), Plcg1 (decreased expression), Prkcg (increased, and then decreased expression), Ptgs2 (increased expression), and no effect on Nos3 and Ptk2