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When an acute injury is not healed for a prolonged period of time, it will largely develop into a chronic injury (Thomopoulos et al., 2005

Free radicals play critical role in generating oxidative stress, which oxidizes dopamine to dopamine quinone and superoxide anion and decreases the NADPH and dopamine metabolized by MOA that produces the 3,4-dihydroxyphenylacetaldehyde, ammonia, and H 2 O 2 , which in turn interacts with Fe ++ to generates the OH free radicals that kill neurons in PD [61, 62]

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10.1186/s13287-022-02963-4 133 LuJ.XuH.LiL.TangX.ZhangY.ZhangD.et al (2024)