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By upregulating HO-1 expression, the entry of Nrf2 into the nucleus is inhibited, and the activation of NF-B and tumor necrosis factor (TNF-) are reduced, thus effectively reducing the inflammatory response (O'Rourke et al., 2024

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Some practitioners implement cycling to theoretically prevent receptor desensitization, provide physiological breaks, or manage costs, though evidence supporting these approaches is limited

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Lipidomics reveals a link between CYP1B1 and SCD1 in promoting obesity