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Consistent with the evidence presented we suggest a positive effect towards re-establishing IGF-1 levels by substitutive therapy only to physiological levels, never above them

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doi: 10.1097/JIM.0000000000000187

As B12 plays an essential role in enhancing the metabolic function of the cells, this nutrient can boost energy release, improve memory and help prevent heart disease

People with pernicious anemia, may benefit from sublingual B12 as they lack intrinsic factor and have a lot of trouble absorbing B12 through their digestive system (Ankar, 2020)