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Excessive lipid peroxidation alters the property of membrane and further damage the proteins and nucleic acids, which is implicated in various human pathologies

doi: 10.1073/pnas.102596199

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2017, Social isolation, loneliness and their relationships with depressive symptoms: A population-based study. Social withdrawal significantly impairs an individuals ability to maintain relationships and engage in community or social activities, contributing to a deepening of depressive symptoms leading to a habit of avoiding people forever, particularly if the underlying depression is not addressed