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This is commonly referred to as neuronal firing. In contrast, influx of negatively charged ions can have inhibitory effects by hyperpolarizing the membrane and thus preventing neuronal firing (15)

Oncotarget 11(35):3286-302 2020 PMC7476735 Bogdani M, Speake C, Dufort MJ, Johnson PY, Larmore MJ, Day AJ, Wight TN, Lernmark A, Greenbaum CJ

In this regard, Liu et al

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