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In other words, malonyl-CoA is a potent regulator of CPT1, the enzyme that transfers the acyl group into the mitochondria where it is oxidized

184 Additionally, there is evidence that germline p53 dysfunction can induce inflammation in a way that is dependent on the NF-kB pathway

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In one animal study, plasma L-carnitine was reduced in obese animals that were fed a high-fat diet for a full year, and this was associated with reduced expression of hepatic regulatory L-carnitine genes

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Once inside the mitochondria, these fatty acids undergo beta-oxidation, a metabolic pathway that breaks them down into acetyl-CoA, which then enters the Krebs cycle to generate adenosine triphosphate (ATP), the bodys main energy currency