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Christy Foster, Department of Pediatrics, The University of Alabama at Birmingham, Birmingham, AL 35294, USA

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In cases examined early in the course of the disease, there may be no gross or microscopic lesions but, in general, pathologic changes are present

doi: 10.3390/ijerph15091828 27 WongSKChinK-YIma-NirwanaS

Acknowledgements This work has been supported by the National Key R&D Program of China (2021YFA0910003 (D.Y.), 2020YFA0713801 (D.Y.)), the National Natural Science Foundation of China (22137003 (D.Y.), 22293051 (Z.G.), 21632008 (H.L.)), the Natural Science Foundation of Jiangsu Province (BK20202004 (Z.G.)), the Fundamental Research Funds for the Central Universities (020514380251 (D.Y.)) and Excellent Research Program of Nanjing University (ZYJH004 (D.Y.))

Alterations of Se homeostasis in the HD model have been observed and a beneficial effect of selenite supplementation in mice expressing mutant huntingtin has been reported