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In one analysis, it was found that NAC reduced depressive symptoms and resulted in an overall increase in functionality

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Funding Open Access funding enabled and organized by CAUL and its Member Institutions

Interestingly, the phosphodiesterase inhibitor Cilostazol (used in peripheral vascular disease treatment) is able to improve cognitive function in mice by increasing the hippocampal production of IGF-I through stimulation of sensory neurons [350]

Phenotypic labels (eg, GSH levels or MTX IC50) were used as continuous labels

In conclusion, enzymatic antioxidants typically serve as components of complicated enzymatic systems that detoxify ROS and regenerate other antioxidants, whereas nonenzymatic antioxidants are smaller molecules capable of directly neutralizing free radicals