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Additionally, pathologies like cancer, diabetes mellitus, cardiovascular diseases, and chronic kidney disease can cause an increase in oxidative stress

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studied the efficacy and safety of IV GSH for skin tone lightening in 25 patients of Pakistani origin in a placebo-controlled trial (1,200 mg given IV twice a week for 6 weeks in the treatment group versus normal saline in control group) [15]

These effects were also demonstrated in clinical trials where flavanols improved insulin sensitivity and decreased HbA1c
