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The high PRLR expression in clinical DCIS and preneoplastic structures in preclinical models is reminiscent of ER expression in many of these lesions [reviewed in (183)], and suggests a role for PRL at this early stage of the disease process

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Bisubstrate inhibitors such as NS1, LL320, and II399 based on adenosyl scaffolds have shown promise in this regard 199,200,201

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