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The medications provided to manage blood sugar levels can also lead to B-12 deficiency, in addition to excessive blood sugar levels harming nerves
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Another strategy to improve sensitivity to leptin is to inhibit the autoinhibitory factors involved in leptin signaling, i.e., suppressor of cytokine signaling-3 and PTP1B

Brain damage in infancy and dietary vitamin B12 deficiency

Widespread siRNA off-target transcript silencing mediated by seed region sequence complementarity
