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In a more recent pilot study on 10 people with rheumatoid arthritis , intramuscular injections of octreotide for three months reduced pain and the number of swollen joints in weeks 8 to 10 but had less effect by week 12 [92]

Lixisenatide reduces amyloid plaques, neurofibrillary tangles and neuroinflammation in an APP/PS1/tau mouse model of Alzheimers disease

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Inflammatory mediators such as cytokines further damage enteric neurons, exacerbating ENS dysfunction

Caloric restriction was one of the first lifespan-extending interventions to be identified