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Interestingly, several fragment hits originating from our second XChem screen possess alternative groups to the sulfonic acid that interact with R131 and R102, which opens up opportunities to link and merge hit matter found across the TIN2 leucine and phenylalanine binding pockets

Additional mechanistic studies demonstrated that both dihexa and Nle'-AnglV, its parent compound, were effective stimulators of hippocampal synaptogenesis thus providing a rational explanation for their pro-cognitive activities

[DOI] [PubMed] [Google Scholar] 38.Hatakeyama M., Opitz L., Russo G., Qi W., Schlapbach R., Rehrauer H

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Roles of neuropathology-associated reactive astrocytes: a systematic review