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First, a bacterial reverse mutation test (Ames test) assessed AOD9604s mutagenic potential using four histidine-dependent auxotrophic mutants of Salmonella typhimurium (TA1535, TA1537, TA98, TA100) and one tryptophan-dependent auxotrophic mutant of Escherichia coli (WP2 uvrA), using both plate incorporation and pre-incubation methods at doses of 0, 1.6, 8, 40, 200, 1,000, and 2,000 g AOD9604/plate

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high heels) relief of symptoms by removing shoes and massaging foot paresthesia most commonly on the plantar aspect of web space Physical exam palpation neuroma may be palpable positive web-space compression test provocative tests Mulder's click bursal click may be elicited by squeezing metatarsals together Drawer test at metatarsal phalangeal joint (MTPJ) assess for MTPJ instability Imaging Radiographs recommended views weight bearing AP/lateral/oblique views findings usually normal may see bony deformity Ultrasound indication non-palpable neuroma with clear clinical presentation findings oval, hypoechoic mass oriented parallel to the metatarsal bones outcomes highly operator dependent MRI indication not usually required for diagnosis may be used to rule out other pathologies Studies Common digital nerve block indication confirmatory for accurate diagnosis of interdigital neuroma findings numbness over lateral surface of toe with relief of patient reported pain Differential consider if there is no relief of pain after well positioned digit nerve block Metatarsalgia Stress fracture MTPJ arthritis Metatarsal head osteonecrosis Neoplasm Lumbar radiculopathy Treatment Nonoperative wide shoe box with firm sole and metatarsal pad indications first line of treatment outcomes results are unpredictable approximately 20% of patients will have complete resolution of symptoms adding anti-inflammatory medications rarely provide any benefit corticosteroid injection indications symptomatic benefit modality usually approached dorsal after isolating the neuroma with palpation or ultrasound outcomes evidence for its effectiveness is weak suggested to provide symptomatic benefit in short term randomized control studies Operative indications failure of nonoperative management techniques dorsal or plantar approach (dorsal most common) neurectomy with nerve burial (bury proximal stump within intrinsic muscles) transverse intermetatarsal ligament release Technique Dorsal neurectomy approach 3 to 4 cm incision just proximal to the involved webspace blunt dissection to avoid injury to branches of superficial peroneal nerve technique spread the metatarsal bones to visualize the webspace, as well as tension the transverse intermetatarsal ligament protecting the neurovacular bundle, transect the transverse intermetatarsal ligament identify the interdigital nerve proximal and distal to the nerve bifurcation resect the nerve at least 3 cm proximal to intermetatarsal ligament reapproximate and repair the transverse intermetatarsal ligament to avoid intermetatarsal head instability Complications Stump neuroma causes include inadequate retraction (traction neuritis) caused by tethering of plantar neural branches that prevent retraction following resection inadequate resection (not proximal enough) most common nerve should be resected at least 3 cm proximal to intermetatarsal ligament resect through plantar or dorsal incision Painful plantar scar increased risk (5%) with plantar incision Create a free account or log in to see the cards.