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Tryptophan, one of the essential aromatic amino acids in the human body, has metabolites such as indoxyl sulfate and p-cresol sulfate that can stimulate the release of GLP-1 and insulin secretion

The BNF recently (2019) changed its guidance for the frequency of injections of hydroxocobalamin: Every 2 months in patients who have neurological symptoms Every 2 or 3 months when there are no neurological symptoms

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