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BMC Pharmacol Toxicol 21:62 Haryuna T-S-H, Munir D, Maria A, Bashiruddin J (2017) The antioxidant effect of curcumin on cochlear fibroblasts in rat models of diabetes mellitus

These alterations result from generation of highly reactive free radicals leading to peroxidation of membrane phospolypids rich in polyunsaturated fatty acids, particularly in conditions with increased intracellular iron and decreased antioxidant systems (namely glutathione) ( Iron plays a crucial role in the synthesis of neurotransmitters in the brain such as DA, epinephrine, norepinephrine and serotonine, and in the production of ATP in the mitochondria through the process of electron transport in an organ like the brain that requires a considerable amount of energy

This complex, multimechanistic pathogenesis underpins the notorious resistance of neuropathic pain to conventional analgesics like opioids and NSAIDs, which primarily target nociceptive transmission rather than the maladaptive neural plasticity and immune signaling that are now central to the condition

& Prausnitz, M

Injections might offer quicker results, but theyre not a magic bullet

Incorporate stress-reducing activities into your routine, such as meditation, yoga, or deep-breathing exercises