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While neurohormonal mediators and cytokines play critical roles in regulating skin functions, their dysregulation can lead to inflammation, pigmentation abnormalities, premature aging, and skin cancers

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Melatonin and melatonin-agonists for metabolic syndrome components in patients treated with antipsychotics: a systematic review and meta-analysis

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It appears that agonists can be measured by IC50 because they do indeed inhibit other ligands from binding while activating the receptor
