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Description
Oxidative stress and mitochondrial damage in the pathogenesis of ALS: new perspectives

This is a stable cellular line derivative from PLB-985 that lacks the gp91 phox subunit of the NADPH oxidase 2 (Nox2), because the gp91 phox gene was knocked out [22], which present a reduction of 3 times in the intracellular ROS levels [8]

doi: 10.1016/j.yebeh.2021.108045 55 LiY.XiaoB.QiuW.YangL.HuB.TianX.et al
[DOI] [PMC free article] [PubMed] [Google Scholar] 218.Feghali M, Venkataramanan R, Caritis S

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We established an in vitro model by treating HK-2 cells with CaOx
