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Dextromethorphan is a weak non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist resulting in glutamate inhibition and protected from first-pass metabolism by its co-drug, quinidine, which was shown to be well tolerated in patients with ALS [184]

Pan Y, Mansfield KD, Bertozzi CC, Rudenko V, Chan DA, Giaccia AJ, et al

This is because patients need to rely strictly on proprioceptive reflexes rather than a combination of vestibular, visual, and proprioceptive reflexes for balance and ambulation

McCarthy, A

doi: 10.1186/s13024-022-00548-6 37 CosolaC.RocchettiM

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