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Mechanistic studies have established that Dihexas procognitive and synaptogenic effects are mediated by the hepatocyte growth factor (HGF) / c-Met receptor system rather than by the classical AT 4 receptor, despite Dihexas structural origin as an angiotensin IV derivative

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[16] There is a particularly marked decline in sleep-related GH secretion, resulting in loss of the nocturnal pulsatile GH secretion seen in younger individuals and lack of a clear night-day GH rhythm

doi: 10.1016/j.scitotenv.2013.02.050

Gupta, S., Jiskoot, W., Schneich, C

Cortical connections position primate area 25 as a keystone for interoception, emotion, and memory