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Notably, studies show that activation of the Nrf2 pathway is associated with the extracellular regulated protein kinases (ERK) signaling pathway

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DJ-1 also regulates STAT1 activation by upregulating the expression of mir-155 [134], which specifically induces expression of suppressor of cytokine signaling 1 (SOCS1), a negative feedback regulator of STAT1 [134]

Transcription factors, such as SREBP-1c (sterol regulatory element-binding protein 1c) and NF-B (nuclear factor kappa-light-chain-enhancer of activated B cells), can regulate the expression of genes encoding key enzymes in methionine metabolism

[DOI] [PubMed] [Google Scholar] 24.Varani J, Spearman D, Perone P, Fligiel SE, Datta SC, Wang ZQ, et al