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The increased NRF2 activation in the cancer leads to secreted metabolites which can affect the tumor microenvironment [78]

Increased levels of lignin helps to fix the cell wall and represents a detoxification mechanism induced by heavy metal stress over long-term evolution in plants [62]

Clearance speed varies with route: intravenous administration clears faster than subcutaneous, and topical application produces negligible systemic absorption but sustained dermal presence