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Finally, they reflect pathways likely additional to those involved in the angiogenesis (Vukojevic et al., 2018), recently associated in particular with the increased expression, internalization of VEGFR2, and the activation of the VEGFR2-Akt-eNOS signaling pathway (Hsieh et al., 2017) (see Genes Expression as Support ), given the rapid presentation of all of these effects, which occurred before the process of angiogenesis could be initiated (Sikiric et al., 1993

These mediators include the inflammasome complex NOD-like receptor thermal protein domain associated protein 3 (NLRP3), and tumor necrosis factor-alpha (TNF-), which in turn exacerbate the dendritic and synaptic impairments leading to neuronal death and promote AD progression [13,14,15]

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Intensities of spots for blank and the housekeeping gene peptidylprolyl isomerase A were used for normalization of the data

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14 Current clinical laboratory methods for GSH determination include chromatographic separations followed by electrochemical detection, derivatization for spectrophotometric detection, or mass spectrometry