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It also would be prudent to consider whether intellectual property interests may restrict the performance of certain tests and other procedures

For oral protocols, purity verification matters as much as for injectable routes impurities can confound experimental results regardless of administration route

doi: 10.1073/pnas.1108190108

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Further studies are necessary to clearly delineate the major NAD + biosynthetic pathways and NAD + consumption routes during macrophage phenotypic transition to determine whether the observed decline in NAD + levels depends on context and time and to determine the molecular mechanisms through which NAD + levels alter macrophage polarization states and functions