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14 Food and Drug Administration

Butler, T

QMP engineering prolongs the ability of the GLP-1 albumin fusion to restrict glycemic excursion in vivo To investigate whether the GLP-1 albumin fusions would stimulate insulin secretion in vivo, we performed a glucose tolerance test (GTT) in human FcRn Tg32 mice (Fig

All experiments were repeated at least twice

In contrast, [U- 13 C]glucose isotope tracing results demonstrated a significant increase in TCA cycle intermediates derived from glucose when GGCT was overexpressed

Altan, M, Li, R, Li, Z, Chen, R, Sheshadri, A, Tran, HT, Little, L, Baguley, J, Sinson, JC, Vokes, N, Gandhi, S, Antonoff, MB , Swisher, SG, Lizee, GA, Reuben, A, Heymach, JV, Zhang, J
