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(A) Intrinsic resistance mechanisms: While mutant KRAS is essential for tumorigenesis, tumor cells can acquire KRAS independence during proliferation through processes such as epithelial-mesenchymal transition (EMT), YAP activation, or metabolic reprogramming

[DOI] [PubMed] [Google Scholar] 65.Rostom A, Dube C, Cranney A, Saloojee N, Sy R, Garritty C, Sampson M, Zhang L, Yazdi F, Mamaladze V, Pan I, MacNeil J, Mack D, Patel D, Moher D

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