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To predict the survival outcomes for CRC patients according to the gene signatures identified in our mouse 10x scRNAseq data, we used the top-expressed genes of the myeloid subclusters C1qc + macrophages, Spp1 + macrophages, and S100a9 + neutrophils

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NAD + is also involved in metabolic switching, or the Warburg effect, in which the main source of energy production is anaerobic glycolysis through fermentation of pyruvate to lactic acid, as opposed to mitochondrial oxidative phosphorylation 340

doi: 10.1016/j.biopha.2019.108635

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Interestingly, neutrophils of the horse lack defensins that depict mostly the main peptide type of these cells in other species