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Native IGF-1 exists as an FDA-approved human drug: recombinant human IGF-1, marketed as mecasermin (brand name Increlex), is approved for the treatment of growth failure in children with severe primary IGF-1 deficiency and in patients who have developed neutralizing antibodies to growth hormone

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Then siRNA-Akt was used to determine that L-carnitine ameliorated cancer cachexia via the Akt/FOXO3/MaFbx