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Together, they provide evidence for the utility of berberine as an adjuvant therapy in addressing a range of resistance and survival pathways in breast cancer

Katsumi K, Ogose A, Hotta T, Hatano H, Kawashima H, Umezu H, et al

By then the lesion can be of quite a considerable size and since they occur in heavily sun-exposed sites, definitive treatment can be a toss-up between curative therapy with severe cosmetic defects or a less aggressive approach taking into account the likelihood of invasive disease occurring and the patients co-morbidities and age

lesions that extend deeper than the epidermis, should be urgently referred to specialist care, and prioritised as having a high suspicion of cancer to ensure they receive treatment within 62 days of receipt of referral