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210,211 Mechanistically, IRF8 binds interferon-stimulated response elements in the promoters of key ATGs, including ATG5, ATG7, MAP1LC3B , and BECN1 , thereby increasing autophagosome formation

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10.1016/j.cell.2018.08.041 Summary Keywords GLP-1, gut microbiota, microbiome, pancreatic -cells, probiotics, single-cell transcriptomics, type 2 diabetes Citation Ruchko E, Chernysheva M, Sokolov V, Starinnov Z, Sabirov M and Vasiliev A (2026) -cell heterogeneity and molecular plasticity in type 2 diabetes: multi-omics perspectives and the role of gut microbiota

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238,239,240 In addition, artemisinin can induce cancer cell death by disrupting cell membranes, as well as induce cell apoptosis, inhibit angiogenesis, proliferation, and migration of endothelial cells, and improve sensitivity to chemotherapy or radiotherapy
