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Endogenous stimuli from the microenvironment The tissue microenvironment has significant characteristics in some special diseases like diabetes, and pathological changes such as changes in or the appearance of pH, ROS, and specific enzymes, occur in the microenvironment

Deficiency in the anti-apoptotic protein DJ-1 promotes intestinal epithelial cell apoptosis and aggravates inflammatory bowel disease via p53

BPC-157 may also have antioxidant properties, helping to protect cells from oxidative damage, and it may interact with the nitric oxide system, potentially contributing to its effects on blood flow and inflammation

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D-CAN is composed of two essential parts: an ASC-binding domain (peptide CSWKYWFGEC) and a pro-apoptotic fragment (Daquinag et al., 2017)

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