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10.1016/j.freeradbiomed.2004.05.030 124 SzalaM.GrzelakowskaA.ModrzejewskaJ.SiarkiewiczP.SowiskiD.wierczyskaM.et al (2020)

During the process of metabolic reprogramming in liver cancer, a substantial quantity of nutrients and metabolites, including lactate, glutamine, and arginine, are released or transported

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As the tumor develops, mutations accumulate in cancer cells and the deregulation of stromal cells leads to both biomechanical and functional changes in the ECM (Kalluri, 2016)