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HCC cells with Rb-negative status promote the occurrence of ferroptosis and cell death upon exposure to sorafenib (Louandre et al., 2015)

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Secondary Radical Species Since free radicals can initiate radical chain reactions in some biological molecules, a number of other free radical species occur in cells as part of these processes

This effect was investigated in the cuprizone induced demyelination model of C57/BL6 mice CNS

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