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Introduction Amodiaquine is a potent anti-malaria drug, however, rare but life-threatening idiosyncratic hepatotoxicity (1/15,500 patients) and agranulocytosis (1/2000 patients) have restricted its therapeutic use (Olliaro and Mussano, 2003

Dopamine replacement therapies such as levodopa (L-DOPA) remain the mainstream clinical treatment for PD [5]

Incubation with Protein Sample (Prey) The immobilized bait is incubated with a cell lysate or purified protein solution containing the prey

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Serine phosphorylation of glutathione S-transferase P1 (GSTP1) by PKC enhances GSTP1-dependent cisplatin metabolism and resistance in human glioma cells

Resveratrol modulates NF-B/JNK/MAPK signaling, SIRT1 activation, and microglial cytokine release, offering neuroinflammatory and anti-amyloid benefitsthough clinical outcomes remain mixed and oral bioavailability low (~0.5%), prompting exploration of improved formulations (48)