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It is still not clear how possession of the APOE 4 allele increases AD risk, but ApoE appears to be required for A aggregation and ApoE 4 has been shown to be the most efficient at promoting such oligomerization (284)

Dostinex may cause severe hypotension with first dose, particularly in Parkinsons patients
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These effects are usually mild and disappear with dosage adjustment
The Expression of the Emotions in Man and Animals, third editionn (New York: Oxford University Press, 1998)