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Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2

On the contrary, lower GSH levels were also recorded among males of Group B, which might be related to several factors, including more rapid utilization against increased oxidative stress caused by testosterone and sex-dependent regulation of GSH metabolism

Klein P, Kaminski RM, Koepp M, Loscher W

In particular, we suspect that acidification of mutant supernatant precludes chemical oxidation of the catecholamine precursor L-DOPA, as this process is supported by an alkaline pH 50 and was reversible by MOPS-buffering of gsh2 mutant media