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Description

Resazurin is a blue dye that is internalized by cells and metabolically reduced by diaphorase activity enzymes to the highly fluorescent pink compound resorufin

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These drugs can induce apoptosis and disrupt cellular homeostasis, leading to irreversible SHL

In all isoforms enzymatic function depends on the conserved peroxidatic cysteine residue contained within an active-site conserved across all isoforms as well as cysteine in the carboxy-terminal region functional in some of the PRDX isoforms