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Moreover, this combined therapy boosted lymphocyte infiltration and led to the sensitization of both local as well as distant tumors to PD-L1 blockade treatment [175]
An example is heroin, an opiate that passes through the BBB 100 times more easily than morphine and is subsequently converted to morphine in the CNS
Nat Chem Biol 2015, 11 (2), 115120
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Shi, M.M., Kugelman, A., Iwamoto, T., Tian, L
