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In cancer cells, the use of glutamate-derived nitrogen for NEAA production may be favored in various types of cancer cells to preserve nitrogen for anabolic reactions 48 and may prevent apoptosis induced by ATF4 activation upon glutamine deprivation 6

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Iron chelators such as DFO can efficaciously reverse abnormal lipid metabolism and hepatic damage induced by high-fat, high-iron diets [790792]

[DOI] [PMC free article] [PubMed] [Google Scholar] 16.Tarrag-Celada J., Foguet C., Tarrado-Castellarnau M., Marin S., Hernndez-Alias X., Perarnau J., Morrish F., Hockenbery D., Gomis R.R., Ruppin E., et al

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Aromatase inhibitors may be considered but are not uniformly effective (41)