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Serious toxicity begins at 7.5 mg/day of prednisone equivalent, which is the borderline between low and medium pharmacological doses

It has been revealed that NF-B gene expression level is downregulated following PANTO treatment by inhibiting the activation of IKK complex and preventing p65 nuclear transfer

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For example, Treg cells, which are indispensable for preventing autoimmunity by braking on the T cell immunity, can suppress the effective tumor immunity