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Many minerals and vitamins are cofactors for enzymes

One type of MDR is based on overexpression of efflux pumps at the plasma membrane, such as P-gp, MRP1, and BCRP, resulting in strongly reduced intracellular drug concentrations [12]

Cysteine is the rate-limiting substrate because its the least abundant of the three

This conservation is not surprising as oxidative stress is an inevitable byproduct of aerobic respiration, and GSH is an important antioxidant that mitigates the effects of reactive oxygen species (ROS), such as hydrogen peroxide

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