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J Asthma 2015

Connective-Tissue Growth Factor (CTGF/CCN2) Contributes to TGF-1-Induced Lung Fibrosis

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Reed GM, First MB, Kogan CS, Hyman SE, Gureje O, Gaebel W, et al

This bidirectionality - whereby leukemic metabolic states shape immune function, and microenvironmental signals in turn reconfigure leukemic metabolism - exemplifies the self-reinforcing circuit proposed as the organizing principle of this perspective, and identifies the convergence of oncometabolite signaling with immune checkpoint biology as a mechanistically compelling frontier for combinatorial therapeutic targeting [Figure 3]

Belsti Y
