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In a diabetic nephropathy (DN) model, rats treated with coenzyme Q10 (CoQ10) or similar drugs, such as mitoquinone mesylate (MitoQ), exhibited improvements in renal function and tubular damage

However, the accumulation of HIF-1 was not accompanied by the expression of HIF-1-controlled angiogenic factors, including VEGF, tyrosine-protein kinase receptor Tie-2, angiopoietin-1 (Ang-1), and FGF-1 in the ischemic myocardium [133]

[DOI] [PMC free article] [PubMed] [Google Scholar] 25.Singh S.V., Warin R., Xiao D., Powolny A.A., Stan S.D., Arlotti J.A., Zeng Y., Hahm E.R., Marynowski S.W., Bommareddy A., et al

10.2165/00128071-200405010-00002 [DOI] [PubMed] [Google Scholar] Yuskaitis C

By contrast, GMP-grade FBS undergoes extensive testing for sterility, endotoxins and viral contaminant, whereas unavoidable batch-to-batch variability can still affect reproducibility, thereby increase overall production costs (van der Valk et al., 2018)

doi: 10.1038/nri797 47 CuiLWangY
