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268 Interrogating LRRK2 Kinase Activity in Human Monocytes Derived from Parkinson's Disease Patients Carrying the Asian LRRK2 G2385R and R1628P Variants TS

This activity is closely related to the molecular structure of this flavonoid, in particular to the presence of -OH groups in the 5 and 7 positions of the B ring, which are responsible for the reducing properties of quercetin (the ability to scavenge radicals) 59

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For instance, the interaction of ZnT1 with LTCCs enables zinc entry from the extracellular space into the cell membrane, thereby contributing to calcium signaling involved in excitation-contraction coupling in skeletal muscle

The higher abundance of these functions in the LP group indicated more relevant metabolism and accordingly better silage results